Reference source : ECHA
Trifluoroacetic Acid (TFA) PFAS Harmonised Classification and Labelling (CLH) CLP Regulation Persistent Mobile and Toxic (PMT) vPvM Reproductive Toxicity Annex VI to CLP
At its 77th meeting held from 1 to5 June 2026, the European Chemicals Agency's (ECHA) Committee for Risk Assessment (RAC) adopted an opinion supporting a harmonised classification and labelling (CLH) for trifluoroacetic acid (TFA), including reproductive toxicity, as well as the recently introduced PMT and vPvM hazard classes, under the Classification, Labelling and Packaging (CLP) Regulation.
TFA is a highly persistent fluorinated substance that has attracted increasing regulatory attention due to its widespread occurrence in the environment. It can be formed through the degradation of several fluorinated substances, including certain refrigerants, plant protection products, and other PFAS-related chemicals.
RAC Supports Reproductive Toxicity and PMT/vPvM Classification
RAC adopted by consensus a proposal to classify TFA (CAS No. 76-05-1) as Reproductive Toxicity Category 1B (H360Df), indicating that the substance may damage the unborn child. The Committee also supported classification as Persistent, Mobile and Toxic (PMT; EUH450) and very Persistent and very Mobile (vPvM; EUH451).
In addition, RAC supported upgrading the inhalation acute toxicity classification from Acute Toxicity Category 4 to Category 3 (H331) and adding Acute Toxicity Category 4 for the oral route (H302). Existing classifications for skin corrosion and aquatic chronic toxicity would be retained.
The Committee also adopted an opinion for sodium trifluoroacetate and other inorganic salts of trifluoroacetic acid, supporting their classification as Reproductive Toxicity
RAC Also Supports Endocrine Disruptor Classification for Resorcinol
During the same meeting, RAC also adopted an opinion supporting the classification of resorcinol as an endocrine disruptor for human health (ED HH 1; EUH380). The Committee adopted further opinions on several other CLH dossiers, including those for bromuconazole and l-carvone, and finalised opinions on the proposed restrictions of octocrylene in cosmetic products and certain chromium(VI) substances. Further details are available in the RAC-77 meeting minutes published by ECHA, available here.
Next Steps
The adopted RAC opinions will now be forwarded to the European Commission, which will decide whether to include the classifications in Annex VI to the CLP Regulation through a future Adaptation to Technical Progress (ATP).