Colombia updated its national profile of chemical substances in 2017, providing detailed information about the chemicals and their quantities in circulation. That same year, the national chemical bill was passed to enhance the regulation and management of these substances. Since then, Colombia has continued to refine its national chemical regulations. The latest document has been the Decree 1630 of 2021, which has become the legal base for establishing a National Inventory and Registry in the country (INSQUI: Inventario Nacional de Sustancias Quimicas). The Registry includes chemical substances identified as priorities or that can cause harm to people and the environment at the quantity of 100 kg or more. The aim is adopting mechanisms and provisions for the integrated management of industrial-use chemicals. This includes managing the risks of chemicals that are identified and classified based on the hazard classes and categories outlined in the United Nations' Globally Harmonized System of Classification and Labelling of Chemicals (GHS), as established in Decree 1496 of 2018 or any regulations that modify or replace it. In 2021 Resolution 773 of 2021 was launched, which defines the actions to be developed by employers for the implementation on GHS.