Drug discovery services
We offer assistance for drug discovery and development action by orchestrating and executing a range of Developmental and Screening assays. These assays assess the impact of the new drug candidate on cellular, molecular, and biochemical levels, forming essential elements of the drug discovery process.
ADME-PK
This is a crucial stage in the drug development process as it decreases the likelihood of post-marketing drug recalls by thoroughly assessing the drug candidates in the early phases. This wiss significantly cutting down the expenses of introducing a new drug to the market.- LC-MS/MS based bioanalysis
- Multiple sample extraction procedures
- Screening of vehicles and excipients for a soluble parenteral formulation
- HPLC based dose confirmation
- Bioavailability studies (IV/PO routes)
- Serial sampling mice PK
- Plasma/Brain distribution
- Chemical-treated models for POC
- PK parameters using WinNonlin
- Major human isoforms 3A4, 2D6 and 2C9
- Clint in liver microsome & Hepatocytes
- Plasma & tissue extracts
- PAMPA
- Caco-2
- Buffer solubility
- LogD7.4
- pH stability in buffer & simulated body fluids
- Plasma stability
In Vivo Pharmacology
Provides valuable insights into the potential effectiveness of the compound in addressing the targeted disease area. We can assist you by creating tailored models for conducting tests and evaluations.- Immune modulation / stimulation model in mice
- Thigh infection model in mice
- Bacterecemia (sepsis)
- Lung infection in mice
- Growth inhibitory effect of essential oils
- Glucose and Cholesterol lowering
- Probiotics in Wellness
- Intra Ocular Pressure (IOP) &
- Glaucoma
- Anti-obesity/Weight gain reduction
- Energy enhancers (AMPK pathway)
- Rodent exercise model for muscle building & endurance
- Intra-Ocular Pressure model in rat
- Colonization of intestine by probiotics in mice
- Xenograft models in nude mice (breast cancer and pancreatic cancer)
- Syngenic models
- Anticancer screening in 3D spheroids
- LPS-induced septicemia in mice
- Carrageenan induced paw edema model in rat & mice
- Obese mice model
- STZ-induced diabetes in rat
- Oral glucose tolerance test (OGTT) in rat
Cell & Microbiology
Our well-equipped microbiology laboratories provide a range of assays and screening options tailored to cellular and microbial research needs.Global Product Compliance (GPC) specializes in Global Regulatory Compliance Solutions across sectors
globally. SSS Europe, a familiar name in chemical regulatory and compliance services now formally belongs
under the umbrella of GPC Holding Sweden.
Since 2008, we have emerged as one of the leading names among Global Regulatory Compliance Service
Providers with Representation services in Europe, Asia and Middle East for respective chemical
regulations.
