Canada Finalizes Assessment on Phosphoric Acid Derivatives Group

zThe Government of Canada has released an update on the Phosphoric Acid Derivatives Group, a set of substances assessed under the Chemicals Management Plan (CMP). The latest publication provides the final conclusions for three priority substances, outlining their potential health and environmental impacts, as well as the regulatory actions being taken under the Canadian Environmental Protection Act, 1999 (CEPA).

The Phosphoric Acid Derivatives assessment forms part of the third phase of the CMP, a federal program designed to systematically evaluate substances on the Domestic Substances List (DSL). While some substances from this group were determined to have minimal exposure and low risk, the targeted regulatory action on trixylyl phosphate ensures that future increases in exposure will be carefully managed.

Substances Under Review

The group includes six substances, with three undergoing a full screening assessment:

• Trixylyl phosphate (CAS RN 25155-23-1)
• Oleyl phosphate (CAS RN 37310-83-1)
• Phosphorous trichloride reaction products with 1,1-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol (CAS RN 119345-01-6)

Regulatory Action on Trixylyl Phosphate

Although trixylyl phosphate is not currently considered harmful at existing exposure levels. However, it has been associated with potential reproductive system effects. Due to this concern, the government has taken a precautionary step by applying the Significant New Activity (SNAc) provisions of CEPA. This means that any proposed new manufacture, import, or use of trixylyl phosphate must be reported and evaluated by regulators before it can proceed.

Substances of Lower Concern

The assessment concluded that no immediate regulatory action is required for oleyl phosphate and the phosphorous trichloride reaction products. These substances are not expected to pose significant risks to health or the environment at current levels of use.

Timeline of Key Milestones

• July 13, 2019: Draft screening assessment published for public comment.
• December 19, 2020: The final screening assessment was released and the government announced its intent to apply SNAc provisions to trixylyl phosphate.
• March 26, 2025: The Canada Gazette publication officially amended the Domestic Substances List (DSL) to apply SNAc provisions to trixylyl phosphate.