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On June 24, 2025, China’s National Medical Products Administration (NMPA) released Announcement No. 61 of 2025 to improve the management of cosmetic ingredients and encourage innovation in the cosmetics industry. The notice introduces updates to the Catalogue of Used Cosmetic Ingredients in China (called the “Catalogue”). 

New Ingredients Added After 3-Year Monitoring 
According to the Cosmetics Supervision and Administration Regulation, cosmetic ingredients that have been registered, filed, and completed a 3-year safety monitoring period without any safety concerns can be added to the Catalogue. The Catalogue is now divided into two parts: 

 

• List I: Based on the 2021 version with updates. 
• List II: For newly added ingredients after safety monitoring. 

Updates to List I: Improved Clarity and Standardization

The NMPA has made the following changes to List I: 

• The “maximum historical use level” is no longer shown. 
• Ingredient names (in Chinese or INCI/English) have been standardized. 
• Notes for some ingredients have been updated based on the Cosmetic Safety Technical Standards.

New Additions to List II

Two new ingredients have been added to List II after completing the required safety monitoring: 

1. N-Acetylneuraminic Acid (CAS no. 131-48-6) 
2. Beta-Alanyl-Hydroxyprolyl-Diaminobutyryl Benzylamide (CAS no. 823202-99-9)

Dynamic Updates from Now On

The Catalogue will be updated regularly based on scientific research, industry needs, and regulatory experience. Updates will no longer be announced by official notices. Instead, the latest version of the Catalogue and explanations for changes will be published on the NMPA website. 

For more details, companies can visit the official notice here   or contact their local environmental authority 

Reference for uploading: https://www.nmpa.gov.cn/xxgk/ggtg/hzhpggtg/jmhzhptg/20250624153604180.html 

On June 24, 2025, China’s National Medical Products Administration (NMPA) announced the dynamic adjustment of the Catalogue of Used Cosmetic Ingredients. This catalogue will now be updated regularly and is divided into two parts: List I and List II. 

Two New Ingredients Added to List II 

Two cosmetic ingredients have recently been added to List II: 

• N-Acetylneuraminic Acid (CAS no 131-48-6), registered by Wuhan Zhongke Guanggu Green Biotechnology Co., Ltd. 

• Beta-Alanyl-Hydroxyprolyl-Diaminobutyryl Benzylamide (CAS no 823202-99-9), registered by Shenzhen Vicky Pharmaceutical R&D Co., Ltd. 

Both ingredients have completed a three-year safety monitoring period and were found to meet the requirements of the Cosmetics Supervision and Administration Regulation and related policies. As a result, they are now officially included in the list of used cosmetic ingredients. 

Updates to List I: Standardization and Clarifications 

In addition, List I has been updated as follows: 

1. The item “Maximum Historical Use Level” has been removed. 

2. The Chinese or INCI/English names of certain ingredients,  (such as No. 01371 and 01372,) have been standardized. 

3. The remarks for certain ingredients (e.g., No. 04696 and 08970) have been updated in accordance with the Cosmetic Safety Technical Standards. 

For more details, companies can refer to the official notice here or contact their local environmental authority 

Reference for uploading: https://www.nmpa.gov.cn/hzhp/hzhpjgdt/20250624154040121.html