News Details
EU Bans 21 CMR Substances in Cosmetics under Regulation (EU) 2025/877
On 15 May 2025, the European Commission published Regulation (EU) 2025/877, which updates Annex II of the EU Cosmetics Regulation (Regulation (EC) No 1223/2009). This amendment adds 21 substances to the list of those prohibited in cosmetic products due to their classification as carcinogenic, mutagenic, or toxic to reproduction (CMR) under Delegated Regulation (EU) 2024/197. The new bans will apply from 1 September 2025 across all EU Member States.
Affected Substances
The new entries include substances used across industrial sectors, such as:
-
Tetrabromobisphenol A and Bisphenol AF, which are often used for flame retardancy and plastic stabilisation.
-
Transfluthrin and clothianidin, which are known for their pesticidal properties.
-
Dibutyltin maleate and dibutyltin oxide, which are used as catalysts and stabilisers in polymers.
-
Aromatic amines such as N,N-dimethyl-p-toluidine.
-
Several reaction mass mixtures involving bisphenol and phosphonium compounds.
Also impacted is trimethylbenzoyl diphenylphosphine oxide (CAS 75980-60-8). Previously permitted for professional nail products, it has now been fully banned due to its classification as toxic for reproduction.
List of Newly Banned Substances in Cosmetics (Annex II)
|
Entry No. |
Substance Name |
CAS Number |
|
1731 |
Trimethylbenzoyl Diphenylphosphine Oxide |
75980-60-8 |
|
1732 |
Tetrabromobisphenol A |
79-94-7 |
|
1733 |
Transfluthrin |
118712-89-3 |
|
1734 |
Clothianidin |
210880-92-5 |
|
1735 |
Benzyl(diethylamino)diphenylphosphonium phenolate |
577705-90-9 |
|
1736 |
Benzyltriphenylphosphonium bisphenol salt |
75768-65-9 |
|
1737 |
Reaction mass of 4,4′-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium phenolate (1:1) |
– |
|
1738 |
Reaction mass of 4,4′-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium bisphenol salt (1:1) |
– |
|
1739 |
Reaction mass of epoxypropoxy alcohols |
– |
|
1740 |
Dibutyltin maleate |
78-04-6 |
|
1741 |
Dibutyltin oxide |
818-08-6 |
|
1742 |
Reaction mass of epoxypropoxy-2,2-bis((2,3-epoxypropoxy)methyl)butane and epoxypropoxy-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane |
– |
|
1743 |
Bisphenol AF |
1478-61-1 |
|
1744 |
Benfluralin |
1861-40-1 |
|
1745 |
N,N-Dimethyl-p-toluidine |
99-97-8 |
|
1746 |
1,4-Benzenediamine, N,N′-mixed Ph and tolyl derivs. |
68953-84-4 |
|
1747 |
4-Nitrosomorpholine |
59-89-2 |
|
1748 |
Difenoconazole |
119446-68-3 |
|
1749 |
4-Methylimidazole |
822-36-6 |
|
1750 |
3,3′-Dimethylbiphenyl-4,4′-diyl diisocyanate |
91-97-4 |
|
1751 |
Foramsulfuron |
173159-57-4 |
Clarification of Cymoxanil Entry in Annex II
The regulation replaces entry 1580 for cymoxanil in Annex II to include a second chemical name and corresponding CAS number (166900-80-7). This change ensures coverage of the chemical identity for both forms of the substance and improves legal clarity. Additionally, entry 311 in Annex III has been deleted.
Compliance Reminder
From 1 September 2025, all cosmetic products containing these substances must be removed from the EU market. Manufacturers, importers, and distributors should carefully review their formulations and update their compliance documentation accordingly.
The full text of the Regulation can be accessed here.
We acknowledge that the above information has been compiled from European Commission.
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