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Release of QSAR Toolbox 4.8: Improved Usability, Transparency and Security

2025-10-08 Reference source : ECHA

ECHA OECD QSAR Toolbox Chemical Hazard Assessment Toxicity Prediction Metabolism Data Software Update Read-Across


The latest version of the OECD QSAR Toolbox version 4.8 has been released, introducing new functionalities and technical improvements to enhance usability, transparency, and data security. The QSAR Toolbox is a freely available software that supports chemical hazard assessment and reduces the need for animal testing. It is developed jointly by the European Chemicals Agency (ECHA), the OECD Environment Directorate, and implemented by the Laboratory of Mathematical Chemistry.

 

Key Enhancements in Version 4.8
The latest update includes several improvements aimed at optimising performance and data handling:

  • Integration of metabolism data: Users can now import and visualise structural data and metadata from metabolism databases, strengthening the analysis of biotransformation processes.
  • New and updated databases and profiles: The update adds new datasets and improves existing ones to expand chemical coverage and enhance predictive accuracy.
  • Updated QSAR documentation: The documentation of QSAR predictions has been revised in line with the OECD QSAR Assessment Framework to ensure greater transparency and consistency.
  • Improved security and support: Updated libraries and software components enhance system stability and data protection.

 

Supporting Regulatory and Research Applications
The OECD QSAR Toolbox continues to support regulatory research applications, enabling data gap filling, read-across, and category formation in chemical safety assessment. Version 4.8 continues to support international efforts to harmonise chemical assessment approaches and minimise animal testing.

The release notes for QSAR Toolbox 4.8 are available here.



We acknowledge that the above information has been compiled from ECHA.

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