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EPA Invites Experts for Peer Review of Draft D4 Risk Evaluation

2025-09-15 Reference source : US EPA

Evaluation Hazard review TSCA Environmental Protection Agency EPA


The U.S. Environmental Protection Agency (EPA) is seeking nominations of qualified scientists to serve as peer reviewers for the draft risk evaluation of octamethylcyclotetrasiloxane (D4) under the Toxic Substances Control Act (TSCA). The peer review will be conducted by the Science Advisory Committee on Chemicals (SACC). 

 

Call for Nominations 

EPA invites nominations of experts by September 25, 2025. Each nomination should include the candidate’s name, affiliation, and contact information, and must be emailed to the OCSPP Peer Review mailbox: OCSPP-PeerReview@epa.gov. 
EPA expects to select seven to eight ad hoc reviewers to assist SACC. 

 

 

Areas of Expertise Sought 

EPA is particularly interested in scientists with expertise in: 

  • Human health hazard identification and risk assessment 

  • Application of the D4 physiologically based pharmacokinetic (PBPK) model 

  • Assessment of uncertainties in exposure and release 

  • Evaluation of bioaccumulation, bioconcentration, biomagnification, and trophic transfer 

  • Human fish consumption impacts, particularly for susceptible subpopulations 

  • Ecological hazard identification and risk assessment 

 

Conflict of Interest Review 

Selected reviewers will need to submit confidential financial disclosure forms. EPA will review these to ensure there are no conflicts of interest or prior involvement in relevant scientific analyses. 

 

Selection and Public Meeting 

EPA’s final reviewer selection will ensure: 

  • Alignment of expertise with the SACC peer review charge 

  • Balanced representation of diverse scientific viewpoints 

The peer review will take place during a virtual public meeting in December 2025. EPA will announce the official meeting dates soon. 

 

Contact 

For additional details, please contact: 
Dr. Alaa Kamel 
Designated Federal Official 
Email: kamel.alaa@epa.gov 



We acknowledge that the above information has been compiled from US EPA .

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