ECHA Asks RAC to Reassess Glyphosate Classification Based on New Information

On 25 June 2025, the European Chemicals Agency (ECHA) formally requested that its Committee for Risk Assessment (RAC) reassess the hazard classification of glyphosate (CAS no 1071-83-6) under Article 77(3)(c) of the REACH Regulation. This decision follows the submission of new scientific evidence during the renewal process for glyphosate’s approval as an active ingredient in plant protection products.

Trigger for the Reassessment: New Genotoxicity Study

The request is primarily driven by the availability of a new in vivo genotoxicity study that was not previously assessed by the RAC in its 2022 evaluation. Conducted as part of the pesticide renewal process, the study has raised questions regarding the potential mutagenic effects of glyphosate.

Focus of the Reassessment

ECHA has asked RAC to:

• Re-examine glyphosate’s classification for carcinogenicity, mutagenicity, and reproductive toxicity (CMR) under CLP Regulation (EC) No 1272/2008.

• Review additional scientific evidence and new information provided during the pesticide renewal process.

• Address public concerns and ensure alignment with the latest EU regulatory decisions.

Current Classification Status

Glyphosate is currently classified in the EU as follows:

• Eye damage 1 (H318): Causes serious eye damage.

• Aquatic chronic 2 (H411): Toxic to aquatic life with long-lasting effects.

Despite ongoing public and scientific debate about its potential health effects, glyphosate is not classified for carcinogenicity, mutagenicity, or reproductive toxicity.

The European Commission’s Implementing Regulation (EU) 2024/197, which renewed glyphosate’s approval, highlighted this data gap. This prompted the Commission to invite ECHA to re-examine the classification in an independent process.

15-Month Deadline for RAC Opinion

ECHA has set a 15-month deadline for RAC to deliver its opinion, ensuring that the process moves forward in a timely and transparent manner.

The reassessment reflects ECHA’s ongoing commitment to ensuring that chemical hazard classifications are based on the latest scientific evidence, while protecting human health and the environment.