acf-interviews-vikas

Panel 2 - How to best tackle forever chemicals and endocrine disruptors? Worldwide views in response to EU´s classification proposals.

The European Commission has put forward a proposal to revise the CLP regulation which introduces additional hazard classes for inter alia endocrine disruptors and persistence and mobility, which it plans to propose also to the UN GHS. You will hear from the moderator how the new hazards classes are defined in the EU and when they could be submitted and concluded by the UN committee. The four stakeholder representatives will express their positions on whether these are the right hazard classes to be added to GHS, whether the EU definitions are the appropriate ones and give their perspective on the upcoming discussions at the UN level on their inclusion in GHS.

About Dr. Vikas Dighe

Dr. Vikas Dighe
M.V.Sc Ph.D. (Animal Biotechnology), Scientist ‘E’ & In-charge, NIRRH & ICMR, India

Dr. Vikas Dighe works as Scientist `E’ and heads the National Centre for Preclinical Reproductive and Genetic Toxicology (NIRRH) at National Institute for Research in Reproductive and Child health (ICMR). Dr. Dighe has more than two decades of experience in animal experimentation mainly the drug development process and has undertaken more than 30 projects where efficacy and safety of the novel molecules has been undertaken following the OECD/ICH guidelines.He hasexpertise in animal model development for PCOS, diabetes, hypothyroidism, Oligospermia, etc.
His current area of research is molecular toxicology and novel drug delivery. His team is currently undertaking studies toevaluate the effect of various endocrine disruptor chemicals on hypothalamus pituitary and gonadal axis atmolecular levels.He has conducted training workshops and organised national and international conferences in laboratory animal science and clinical pharmacology. He is also serves as GLP inspectorfor National GLP Compliance Monitoring Authority (NGCMA), DST, GOVT of India to accredit GLP certification based on OECD principles. He has published 44 research papers and has written two chaptersof a book as well.

Interview of Dr. Vikas Dighe

Expert Insights Unveil Challenges and Solutions in Managing Forever Chemicals and Endocrine Disruptors at ACF 2023

Interviewer expertise

During the ACF a groundbreaking discussion was led by Dr. Vikas Dighe, shedding light on critical issues surrounding forever chemicals and endocrine disruptors. Dr. Dighe's insights were structured around key questions, providing valuable perspectives on the challenges faced and potential solutions in managing these hazardous substances.

Forever Chemicals in Focus: Dr. Dighe Advocates Vigilance

Addressing the complexities surrounding 'forever chemicals,' or PFASs, Mr Mereu called for a nuanced approach. With Europe leading the way with its proposal to restrict around 14,000 substances, the expertcalled for a case-by-case assessment to address different concerns and substitution possibilities. This balanced view underlines the need for detailed consideration based on use and exposure, rather than broad generalizations.

India's Fight Against Endocrine Disruptors: A Call for Grassroots Advocacy

Discussing India's challenges in managing endocrine-disrupting chemicals, Dr. Dighe acknowledged the government’s efforts but expressed concern about the widespread use of these disruptors in a variety of products due to a lack of awareness. He stressed the importance of grassroots advocacy and education and suggested practical solutions such as switching from plastic to traditional materials.

Understanding the Complex Link Between Reproductive Toxicity and Endocrine Disruptors

Dr. Dighe explained the intricate relationship between reproductive toxicity and endocrine disruptors. While clarifying that not all reproductive toxicants are necessarily endocrine disruptors, he emphasised the need for cautious exposure management and the use of antioxidants to overcome the challenges of reproductive toxicity.

Harnessing Technology: Dr. Dighe Recommends Specialized Software Solutions

Highlighting the key role of bioinformatics and data mining, Dr. Dighe recommended specialised software such as EDC Predictor and ED Tox. These tools, which use machine learning to assess chemical properties and potential toxicity, provide a robust approach to the challenge of managing hazardous chemicals.

The Future Vision of ACF: A Holistic Approach Towards Environmental Safety

In his closing remarks, Dr. Dighe emphasised the importance of a balanced approach in forums such as ACF 2023. Beyond legislation, he urged participants to consider the health and environmental impact of endocrine disruptors. He suggested that these important aspects should be included in future ACF events alongside regulatory discussions, outlining a holistic vision for environmental safety and public health.

Conclusion

Dr. Vikas Dighe's expert insights at ACF 2023 provide a roadmap for addressing the challenges associated with persistent chemicals and endocrine disruptors. By advocating awareness, cautious management, and advanced software applications, Dr. Dighe's recommendations pave the way for a safer and healthier future, that addresses environmental concerns on a global scale.

Vikas Dighe