Drug discovery services

Drug discovery services
LAB Service Request

We offer assistance for drug discovery and development action by orchestrating and executing a range of Developmental and Screening assays. These assays assess the impact of the new drug candidate on cellular, molecular, and biochemical levels, forming essential elements of the drug discovery process.

ADME-PK
This is a crucial stage in the drug development process as it decreases the likelihood of post-marketing drug recalls by thoroughly assessing the drug candidates in the early phases. This wiss significantly cutting down the expenses of introducing a new drug to the market.
Pharmacokinetics (Rodents)
  • Bioavailability studies (IV/PO routes)
    • Serial sampling mice PK
    • Plasma/Brain distribution
    • Chemical-treated models for POC
    • PK parameters using WinNonlin
CYP450 Inhibition
  • Major human isoforms 3A4, 2D6 and 2C9
Metabolism
  • Clint in liver microsome & Hepatocytes
Protein Binding (RED method)
  • Plasma & tissue extracts
Permeability
  • PAMPA
  • Caco-2
Physico-Chemical Assays
  • Buffer solubility
  • LogD7.4
  • pH stability in buffer & simulated body fluids
  • Plasma stability
Bioanalysis
  • LC-MS/MS based bioanalysis
  • Multiple sample extraction procedures
Formulation Screening
  • Screening of vehicles and excipients for a soluble parenteral formulation
  • HPLC based dose confirmation
Cell & Microbiology
Our well-equipped microbiology laboratories provide a range of assays and screening options tailored to cellular and microbial research needs.
Cytotoxicity in 2D and 3D Models

None!
  • Antimicrobial Screening (MIC)
  • Muscle Development (C2C12 Myoblasts)
  • Glucose Uptake (3T3 cells) (Luminescence Based)
  • ELISA
In Vivo Pharmacology
Provides valuable insights into the potential effectiveness of the compound in addressing the targeted disease area. We can assist you by creating tailored models for conducting tests and evaluations.
Immune Modulation
  • Immune modulation / stimulation model in mice
Anti-Bacterial
  • Thigh infection model in mice
  • Bacterecemia (sepsis)
  • Lung infection in mice
  • Growth inhibitory effect of essential oils
Exercise Endurance & Muscle Development
  • Rodent exercise model for muscle building & endurance
  • Intra-Ocular Pressure model in rat
  • Colonization of intestine by probiotics in mice
Oncology
  • Xenograft models in nude mice (breast cancer and pancreatic cancer)
  • Syngenic models
  • Anticancer screening in 3D spheroids
Inflammation / Sepsis
  • LPS-induced septicemia in mice
  • Carrageenan induced paw edema model in rat & mice
Diabetes Models
  • Obese mice model
  • STZ-induced diabetes in rat
  • Oral glucose tolerance test (OGTT) in rat
Nutraceuticals / Wellness
  • Glucose and Cholesterol lowering
  • Probiotics in Wellness
  • Intra Ocular Pressure (IOP) &
  • Glaucoma
  • Anti-obesity/Weight gain reduction
  • Energy enhancers (AMPK pathway)
ACF GHS Report